Thyrotroph and gonadotroph adenomas

Thyrotroph and gonadotroph adenomas, hyper-secrete thyroid-stimulating hormone (TSH) and gonadotropins respectively, are extremely rare, and usually manifest as non-functioning. These adenomas, if large enough, can present with:

  • Visual disturbances (diplopia, bitemporal hemianopsia)
  • neurological symptoms (headache)
  • Hormonal deficiencies (hypopituitarism). The most common clinical deficiency is that of gonadotropins leading to hypogonadism: menstrual cycle abnormalities in women, erectile dysfunction in men and infertility.
  • Hyperthyroidism
  • Goiter
  • Menstrual abnormalities, ovarian hyperstimulation syndrome, hypogonadism
  • Precocious puberty
  • Asymptomatic
  • Random finding