{"id":5818,"date":"2021-06-08T12:10:54","date_gmt":"2021-06-08T12:10:54","guid":{"rendered":"https:\/\/www.pavlatou.gr\/?page_id=5818"},"modified":"2024-04-22T11:18:01","modified_gmt":"2024-04-22T11:18:01","slug":"corticotroph-adenomas-cushing-s-disease","status":"publish","type":"page","link":"https:\/\/www.pavlatou.gr\/en\/corticotroph-adenomas-cushing-s-disease\/","title":{"rendered":"Corticotroph Adenomas &#8211; Cushing&#8217;s Disease"},"content":{"rendered":"\t<section class=\"section\" id=\"section_1960648095\">\n\t\t<div class=\"bg section-bg fill bg-fill  bg-loaded\" >\n\n\t\t\t\n\t\t\t\n\t\t\t\n\n\t\t<\/div>\n\n\t\t\n\n\t\t<div class=\"section-content relative\">\n\t\t\t\n\n  <div class=\"banner has-hover\" id=\"banner-896487145\">\n          <div class=\"banner-inner fill\">\n        <div class=\"banner-bg fill\" >\n            <div class=\"bg fill bg-fill \"><\/div>\n                        <div class=\"overlay\"><\/div>            \n                    <\/div>\n\t\t\n        <div class=\"banner-layers container\">\n            <div class=\"fill banner-link\"><\/div>            \n   <div id=\"text-box-1172648410\" class=\"text-box banner-layer x0 md-x0 lg-x0 y50 md-y50 lg-y50 res-text\">\n                                <div class=\"text-box-content text dark\">\n              \n              <div class=\"text-inner text-left\">\n                  \n\t<div id=\"text-3351738631\" class=\"text\">\n\t\t\n<h3>CORTICOTROPH ADENOMAS &#8211; CUSHING&#8217;S DISEASE<\/h3>\n<p>Cushing&#8217;s disease is caused by excess secretion of adrenocorticotropic hormone (ACTH) leading to hypercortisolemia with multiple complications.<\/p>\n\t\t\n<style>\n#text-3351738631 {\n  color: rgb(255,255,255);\n}\n#text-3351738631 > * {\n  color: rgb(255,255,255);\n}\n<\/style>\n\t<\/div>\n\t\n              <\/div>\n           <\/div>\n                            \n<style>\n#text-box-1172648410 .text-box-content {\n  background-color: rgba(255, 255, 255, 0.16);\n  font-size: 100%;\n}\n#text-box-1172648410 .text-inner {\n  padding: 0px 0px 0px 20px;\n}\n#text-box-1172648410 {\n  width: 60%;\n}\n<\/style>\n    <\/div>\n \n        <\/div>\n      <\/div>\n\n            \n<style>\n#banner-896487145 {\n  padding-top: 600px;\n}\n#banner-896487145 .bg.bg-loaded {\n  background-image: url(https:\/\/www.pavlatou.gr\/wp-content\/uploads\/2024\/04\/corticotroph-adenomas-1200x800.jpg);\n}\n#banner-896487145 .overlay {\n  background-color: rgba(0, 0, 0, 0.17);\n}\n<\/style>\n  <\/div>\n\n\n\t\t<\/div>\n\n\t\t\n<style>\n#section_1960648095 {\n  padding-top: 30px;\n  padding-bottom: 30px;\n}\n<\/style>\n\t<\/section>\n\t\n\t<section class=\"section\" id=\"section_287575021\">\n\t\t<div class=\"bg section-bg fill bg-fill  bg-loaded\" >\n\n\t\t\t\n\t\t\t\n\t\t\t\n\n\t\t<\/div>\n\n\t\t\n\n\t\t<div class=\"section-content relative\">\n\t\t\t\n<div class=\"row\"  id=\"row-1765073531\">\n\n\t<div id=\"col-1323854660\" class=\"col medium-3 small-12 large-3 col-divided\"  >\n\t\t\t\t<div class=\"col-inner text-left\"  >\n\t\t\t\n\t\t\t\n\t<div class=\"ux-menu stack stack-col justify-start ux-menu--divider-solid\">\n\t\t\n\t<div class=\"ux-menu-link flex menu-item first-menu-item\">\n\t\t<a class=\"ux-menu-link__link flex\" href=\"https:\/\/www.pavlatou.gr\/en\/corticotroph-adenomas-cushing-s-disease\/#1\" >\n\t\t\t\t\t\t<span class=\"ux-menu-link__text\">\n\t\t\t\tWhat are Corticotroph adenomas - Cushing&#039;s disease\t\t\t<\/span>\n\t\t<\/a>\n\t<\/div>\n\t\n\t<div class=\"ux-menu-link flex menu-item first-menu-item\">\n\t\t<a class=\"ux-menu-link__link flex\" href=\"https:\/\/www.pavlatou.gr\/en\/corticotroph-adenomas-cushing-s-disease\/#2\" >\n\t\t\t\t\t\t<span class=\"ux-menu-link__text\">\n\t\t\t\tWhat is Cushing&#039;s disease?\t\t\t<\/span>\n\t\t<\/a>\n\t<\/div>\n\t\n\t<div class=\"ux-menu-link flex menu-item first-menu-item\">\n\t\t<a class=\"ux-menu-link__link flex\" href=\"https:\/\/www.pavlatou.gr\/en\/corticotroph-adenomas-cushing-s-disease\/#3\" >\n\t\t\t\t\t\t<span class=\"ux-menu-link__text\">\n\t\t\t\tHow common is it?\t\t\t<\/span>\n\t\t<\/a>\n\t<\/div>\n\t\n\t<div class=\"ux-menu-link flex menu-item first-menu-item\">\n\t\t<a class=\"ux-menu-link__link flex\" href=\"https:\/\/www.pavlatou.gr\/en\/corticotroph-adenomas-cushing-s-disease\/#4\" >\n\t\t\t\t\t\t<span class=\"ux-menu-link__text\">\n\t\t\t\tWhat are the symptoms and signs?\t\t\t<\/span>\n\t\t<\/a>\n\t<\/div>\n\t\n\t<div class=\"ux-menu-link flex menu-item first-menu-item\">\n\t\t<a class=\"ux-menu-link__link flex\" href=\"https:\/\/www.pavlatou.gr\/en\/corticotroph-adenomas-cushing-s-disease\/#5\" >\n\t\t\t\t\t\t<span class=\"ux-menu-link__text\">\n\t\t\t\tHow is Cushing&#039;s disease diagnosed?\t\t\t<\/span>\n\t\t<\/a>\n\t<\/div>\n\t\n\t<div class=\"ux-menu-link flex menu-item first-menu-item\">\n\t\t<a class=\"ux-menu-link__link flex\" href=\"https:\/\/www.pavlatou.gr\/en\/corticotroph-adenomas-cushing-s-disease\/#6\" >\n\t\t\t\t\t\t<span class=\"ux-menu-link__text\">\n\t\t\t\tHow is Cushing&#039;s disease treated?\t\t\t<\/span>\n\t\t<\/a>\n\t<\/div>\n\t\n\t<\/div>\n\t\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\n\t\n\n\t<div id=\"col-1421612531\" class=\"col medium-8 small-12 large-8\"  >\n\t\t\t\t<div class=\"col-inner\"  >\n\t\t\t\n\t\t\t\n<h3 id=\"1\" style=\"font-size: 20px;\">What are Corticotroph adenomas &#8211; Cushing&#8217;s disease<\/h3>\n<div class=\"is-divider divider clearfix\" style=\"max-width:30%;background-color:rgb(155, 0, 128);\"><\/div>\n\t<div id=\"gap-313926121\" class=\"gap-element clearfix\" style=\"display:block; height:auto;\">\n\t\t\n<style>\n#gap-313926121 {\n  padding-top: 20px;\n}\n<\/style>\n\t<\/div>\n\t\n<p>Corticotroph adenoma is a tumour of the pituitary gland that secretes excess adrenocorticotropic hormone (ACTH) and causes Cushing&#8217;s disease.<\/p>\n<a href=\"https:\/\/www.pavlatou.gr\/en\/corticotroph-adenomas-cushing-s-disease\/#1\" class=\"button secondary is-link is-xsmall lowercase\"  >\n    <span>Top<\/span>\n  <i class=\"icon-angle-right\" aria-hidden=\"true\" ><\/i><\/a>\n\n\t<div id=\"gap-549771749\" class=\"gap-element clearfix\" style=\"display:block; height:auto;\">\n\t\t\n<style>\n#gap-549771749 {\n  padding-top: 50px;\n}\n<\/style>\n\t<\/div>\n\t\n<h3 id=\"2\" style=\"font-size: 20px;\">What is Cushing&#8217;s disease?<\/h3>\n<div class=\"is-divider divider clearfix\" style=\"max-width:30%;background-color:rgb(155, 0, 128);\"><\/div>\n\t<div id=\"gap-249323303\" class=\"gap-element clearfix\" style=\"display:block; height:auto;\">\n\t\t\n<style>\n#gap-249323303 {\n  padding-top: 20px;\n}\n<\/style>\n\t<\/div>\n\t\n<p>Cushing&#8217;s disease is a rare condition caused by hypersecretion of the adrenocorticotropic hormone (ACTH) from the pituitary gland leading to increased secretion of cortisol by the adrenal glands. Increased levels of cortisol in the blood (hypercortisolaemia) have systemic consequences as they cause complications from various organs of the body. Severe hypercortisolaemia can be life-threatening.<\/p>\n<a href=\"https:\/\/www.pavlatou.gr\/en\/corticotroph-adenomas-cushing-s-disease\/#1\" class=\"button secondary is-link is-xsmall lowercase\"  >\n    <span>Top<\/span>\n  <i class=\"icon-angle-right\" aria-hidden=\"true\" ><\/i><\/a>\n\n\t<div id=\"gap-1671488079\" class=\"gap-element clearfix\" style=\"display:block; height:auto;\">\n\t\t\n<style>\n#gap-1671488079 {\n  padding-top: 50px;\n}\n<\/style>\n\t<\/div>\n\t\n<h3 id=\"3\" style=\"font-size: 20px;\">How common is it?<\/h3>\n<div class=\"is-divider divider clearfix\" style=\"max-width:30%;background-color:rgb(155, 0, 128);\"><\/div>\n\t<div id=\"gap-536304836\" class=\"gap-element clearfix\" style=\"display:block; height:auto;\">\n\t\t\n<style>\n#gap-536304836 {\n  padding-top: 20px;\n}\n<\/style>\n\t<\/div>\n\t\n<p>Corticotroph adenomas occur less frequently (2%) and their incidence is 0.17 per 100,000.<\/p>\n<a href=\"https:\/\/www.pavlatou.gr\/en\/corticotroph-adenomas-cushing-s-disease\/#1\" class=\"button secondary is-link is-xsmall lowercase\"  >\n    <span>Top<\/span>\n  <i class=\"icon-angle-right\" aria-hidden=\"true\" ><\/i><\/a>\n\n\t<div id=\"gap-1403230117\" class=\"gap-element clearfix\" style=\"display:block; height:auto;\">\n\t\t\n<style>\n#gap-1403230117 {\n  padding-top: 50px;\n}\n<\/style>\n\t<\/div>\n\t\n<h3 id=\"4\" style=\"font-size: 20px;\">What are the symptoms and signs?<\/h3>\n<div class=\"is-divider divider clearfix\" style=\"max-width:30%;background-color:rgb(155, 0, 128);\"><\/div>\n\t<div id=\"gap-554201582\" class=\"gap-element clearfix\" style=\"display:block; height:auto;\">\n\t\t\n<style>\n#gap-554201582 {\n  padding-top: 20px;\n}\n<\/style>\n\t<\/div>\n\t\n<p>The clinical syndrome that Cushing&#8217;s disease manifests with, includes symptoms and signs such as:<\/p>\n<ul>\n<li>Abdominal obesity<\/li>\n<li>Facial roundness (moon face)<\/li>\n<li>fat accumulation at the base of the neck (buffalo hump)<\/li>\n<li>hypertension<\/li>\n<li>acne<\/li>\n<li>bruising<\/li>\n<li>stretch marks (purple striae)<\/li>\n<li>psychiatric manifestations (anxiety, depression)<\/li>\n<li>menstrual disorders<\/li>\n<li>osteopenia, osteoporosis<\/li>\n<\/ul>\n<a href=\"https:\/\/www.pavlatou.gr\/en\/corticotroph-adenomas-cushing-s-disease\/#1\" class=\"button secondary is-link is-xsmall lowercase\"  >\n    <span>Top<\/span>\n  <i class=\"icon-angle-right\" aria-hidden=\"true\" ><\/i><\/a>\n\n\t<div id=\"gap-1586461266\" class=\"gap-element clearfix\" style=\"display:block; height:auto;\">\n\t\t\n<style>\n#gap-1586461266 {\n  padding-top: 50px;\n}\n<\/style>\n\t<\/div>\n\t\n<h3 id=\"5\" style=\"font-size: 20px;\">How is Cushing&#8217;s disease diagnosed?<\/h3>\n<div class=\"is-divider divider clearfix\" style=\"max-width:30%;background-color:rgb(155, 0, 128);\"><\/div>\n\t<div id=\"gap-2042390681\" class=\"gap-element clearfix\" style=\"display:block; height:auto;\">\n\t\t\n<style>\n#gap-2042390681 {\n  padding-top: 20px;\n}\n<\/style>\n\t<\/div>\n\t\n<p>Cushing&#8217;s disease is diagnosed by a series of blood tests and imaging studies. Endocrine dynamic tests play a predominant role in documentation of hypercortisolaemia. Often the diagnosis of the disease can be quite difficult, so experience and a specialised centre are required.<\/p>\n<a href=\"https:\/\/www.pavlatou.gr\/en\/corticotroph-adenomas-cushing-s-disease\/#1\" class=\"button secondary is-link is-xsmall lowercase\"  >\n    <span>Top<\/span>\n  <i class=\"icon-angle-right\" aria-hidden=\"true\" ><\/i><\/a>\n\n\t<div id=\"gap-427456674\" class=\"gap-element clearfix\" style=\"display:block; height:auto;\">\n\t\t\n<style>\n#gap-427456674 {\n  padding-top: 50px;\n}\n<\/style>\n\t<\/div>\n\t\n<h3 id=\"6\" style=\"font-size: 20px;\">How is Cushing&#8217;s disease treated?<\/h3>\n<div class=\"is-divider divider clearfix\" style=\"max-width:30%;background-color:rgb(155, 0, 128);\"><\/div>\n\t<div id=\"gap-1922944711\" class=\"gap-element clearfix\" style=\"display:block; height:auto;\">\n\t\t\n<style>\n#gap-1922944711 {\n  padding-top: 20px;\n}\n<\/style>\n\t<\/div>\n\t\n<p>The treatment of choice for Cushing&#8217;s disease\/corticotroph adenoma is transsphenoidal microadenomectomy. However, sometimes radiotherapy, pharmacotherapy or combinations of the above may be needed.<\/p>\n<a href=\"https:\/\/www.pavlatou.gr\/en\/corticotroph-adenomas-cushing-s-disease\/#1\" class=\"button secondary is-link is-xsmall lowercase\"  >\n    <span>Top<\/span>\n  <i class=\"icon-angle-right\" aria-hidden=\"true\" ><\/i><\/a>\n\n\t<div id=\"gap-110014676\" class=\"gap-element clearfix\" style=\"display:block; height:auto;\">\n\t\t\n<style>\n#gap-110014676 {\n  padding-top: 50px;\n}\n<\/style>\n\t<\/div>\n\t\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\n\t\n<\/div>\n\t\t<\/div>\n\n\t\t\n<style>\n#section_287575021 {\n  padding-top: 30px;\n  padding-bottom: 30px;\n}\n<\/style>\n\t<\/section>\n\t\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":5,"featured_media":0,"parent":0,"menu_order":535,"comment_status":"closed","ping_status":"closed","template":"page-blank.php","meta":{"footnotes":""},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.1 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Cushing&#039;s disease symptoms and treatment by Dr. Maria Pavlatou |<\/title>\n<meta name=\"description\" content=\"Diagnosis and treatment of Cushing&#039;s disease symptoms by the experienced endocrinologist-diabetologist Dr. Maria Pavlatou.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pavlatou.gr\/en\/corticotroph-adenomas-cushing-s-disease\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Cushing&#039;s disease symptoms and treatment by Dr. Maria Pavlatou |\" \/>\n<meta property=\"og:description\" content=\"Diagnosis and treatment of Cushing&#039;s disease symptoms by the experienced endocrinologist-diabetologist Dr. Maria Pavlatou.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.pavlatou.gr\/en\/corticotroph-adenomas-cushing-s-disease\/\" \/>\n<meta property=\"og:site_name\" content=\"\u0394\u03c1. \u039c\u03b1\u03c1\u03af\u03b1 \u03a0\u03b1\u03c5\u03bb\u03ac\u03c4\u03bf\u03c5 MD PhD \u0394\u03b9\u03b1\u03b2\u03b7\u03c4\u03bf\u03bb\u03cc\u03b3\u03bf\u03c2 \u0395\u03bd\u03b4\u03bf\u03ba\u03c1\u03b9\u03bd\u03bf\u03bb\u03cc\u03b3\u03bf\u03c2. \u0394\u03b9\u03b5\u03c5\u03b8\u03cd\u03bd\u03c4\u03c1\u03b9\u03b1 \u0395\u03bd\u03b4\u03bf\u03ba\u03c1\u03b9\u03bd\u03bf\u03bb\u03bf\u03b3\u03af\u03b1\u03c2, \u03a3\u03b1\u03ba\u03c7\u03b1\u03c1\u03ce\u03b4\u03b7 \u0394\u03b9\u03b1\u03b2\u03ae\u03c4\u03b7 \u03ba\u03b1\u03b9 \u039c\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03b9\u03c3\u03bc\u03bf\u03cd \u0399\u03b1\u03c4\u03c1\u03b9\u03ba\u03bf\u03cd \u0391\u03b8\u03b7\u03bd\u03ce\u03bd.\" \/>\n<meta property=\"article:modified_time\" content=\"2024-04-22T11:18:01+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.pavlatou.gr\/en\/corticotroph-adenomas-cushing-s-disease\/\",\"url\":\"https:\/\/www.pavlatou.gr\/en\/corticotroph-adenomas-cushing-s-disease\/\",\"name\":\"Cushing's disease symptoms and treatment by Dr. Maria Pavlatou |\",\"isPartOf\":{\"@id\":\"https:\/\/www.pavlatou.gr\/en\/#website\"},\"datePublished\":\"2021-06-08T12:10:54+00:00\",\"dateModified\":\"2024-04-22T11:18:01+00:00\",\"description\":\"Diagnosis and treatment of Cushing's disease symptoms by the experienced endocrinologist-diabetologist Dr. Maria Pavlatou.\",\"breadcrumb\":{\"@id\":\"https:\/\/www.pavlatou.gr\/en\/corticotroph-adenomas-cushing-s-disease\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.pavlatou.gr\/en\/corticotroph-adenomas-cushing-s-disease\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.pavlatou.gr\/en\/corticotroph-adenomas-cushing-s-disease\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u0391\u03c1\u03c7\u03b9\u03ba\u03ae\",\"item\":\"https:\/\/www.pavlatou.gr\/en\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Corticotroph Adenomas &#8211; 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