{"id":5467,"date":"2021-03-05T08:27:41","date_gmt":"2021-03-05T08:27:41","guid":{"rendered":"https:\/\/www.pavlatou.gr\/?page_id=5467"},"modified":"2024-04-01T08:03:09","modified_gmt":"2024-04-01T08:03:09","slug":"congenital-adrenal-hyperplasia","status":"publish","type":"page","link":"https:\/\/www.pavlatou.gr\/en\/congenital-adrenal-hyperplasia\/","title":{"rendered":"Congenital Adrenal Hyperplasia"},"content":{"rendered":"\t<section class=\"section\" id=\"section_186747491\">\n\t\t<div class=\"bg section-bg fill bg-fill  bg-loaded\" >\n\n\t\t\t\n\t\t\t\n\t\t\t\n\n\t\t<\/div>\n\n\t\t\n\n\t\t<div class=\"section-content relative\">\n\t\t\t\n\n  <div class=\"banner has-hover\" id=\"banner-1571660573\">\n          <div class=\"banner-inner fill\">\n        <div class=\"banner-bg fill\" >\n            <div class=\"bg fill bg-fill \"><\/div>\n                        <div class=\"overlay\"><\/div>            \n                    <\/div>\n\t\t\n        <div class=\"banner-layers container\">\n            <div class=\"fill banner-link\"><\/div>            \n   <div id=\"text-box-823278470\" class=\"text-box banner-layer x0 md-x0 lg-x0 y50 md-y50 lg-y50 res-text\">\n                                <div class=\"text-box-content text dark\">\n              \n              <div class=\"text-inner text-left\">\n                  \n<h3>CONGENITAL ADRENAL HYPERPLASIA<\/h3>\n<p>Congenital adrenal hyperplasia is a genetic disease caused by the lack of an enzyme and can lead to virilization of the female fetuses<\/p>\n              <\/div>\n           <\/div>\n                            \n<style>\n#text-box-823278470 .text-box-content {\n  background-color: rgba(255, 255, 255, 0.16);\n  font-size: 100%;\n}\n#text-box-823278470 .text-inner {\n  padding: 0px 0px 0px 20px;\n}\n#text-box-823278470 {\n  width: 60%;\n}\n<\/style>\n    <\/div>\n \n        <\/div>\n      <\/div>\n\n            \n<style>\n#banner-1571660573 {\n  padding-top: 600px;\n}\n#banner-1571660573 .bg.bg-loaded {\n  background-image: url(https:\/\/www.pavlatou.gr\/wp-content\/uploads\/2021\/03\/adrenal-glands.jpg);\n}\n#banner-1571660573 .overlay {\n  background-color: rgba(0, 0, 0, 0.17);\n}\n<\/style>\n  <\/div>\n\n\n\t\t<\/div>\n\n\t\t\n<style>\n#section_186747491 {\n  padding-top: 30px;\n  padding-bottom: 30px;\n}\n<\/style>\n\t<\/section>\n\t\n\t<section class=\"section\" id=\"section_669181423\">\n\t\t<div class=\"bg section-bg fill bg-fill  bg-loaded\" >\n\n\t\t\t\n\t\t\t\n\t\t\t\n\n\t\t<\/div>\n\n\t\t\n\n\t\t<div class=\"section-content relative\">\n\t\t\t\n<div class=\"row\"  id=\"row-1720486109\">\n\n\t<div id=\"col-186780010\" class=\"col medium-3 small-12 large-3 col-divided\"  >\n\t\t\t\t<div class=\"col-inner text-left\"  >\n\t\t\t\n\t\t\t\n\t<div class=\"ux-menu stack stack-col justify-start ux-menu--divider-solid\">\n\t\t\n\t<div class=\"ux-menu-link flex menu-item first-menu-item\">\n\t\t<a class=\"ux-menu-link__link flex\" href=\"https:\/\/www.pavlatou.gr\/en\/congenital-adrenal-hyperplasia\/#ti-einai\" >\n\t\t\t\t\t\t<span class=\"ux-menu-link__text\">\n\t\t\t\tWhat is Congenital Adrenal Hyperplasia?\t\t\t<\/span>\n\t\t<\/a>\n\t<\/div>\n\t\n\t<div class=\"ux-menu-link flex menu-item first-menu-item\">\n\t\t<a class=\"ux-menu-link__link flex\" href=\"https:\/\/www.pavlatou.gr\/en\/congenital-adrenal-hyperplasia\/#aitia\" >\n\t\t\t\t\t\t<span class=\"ux-menu-link__text\">\n\t\t\t\tWhat is the cause of congenital adrenal hyperplasia?\t\t\t<\/span>\n\t\t<\/a>\n\t<\/div>\n\t\n\t<div class=\"ux-menu-link flex menu-item first-menu-item\">\n\t\t<a class=\"ux-menu-link__link flex\" href=\"https:\/\/www.pavlatou.gr\/en\/congenital-adrenal-hyperplasia\/#klhronomikothta\" >\n\t\t\t\t\t\t<span class=\"ux-menu-link__text\">\n\t\t\t\tIf I have the disease, will I pass it on to my child?\t\t\t<\/span>\n\t\t<\/a>\n\t<\/div>\n\t\n\t<div class=\"ux-menu-link flex menu-item first-menu-item\">\n\t\t<a class=\"ux-menu-link__link flex\" href=\"https:\/\/www.pavlatou.gr\/en\/congenital-adrenal-hyperplasia\/#syxnothta\" >\n\t\t\t\t\t\t<span class=\"ux-menu-link__text\">\n\t\t\t\tWhat is the incidence of the disease?\t\t\t<\/span>\n\t\t<\/a>\n\t<\/div>\n\t\n\t<div class=\"ux-menu-link flex menu-item first-menu-item\">\n\t\t<a class=\"ux-menu-link__link flex\" href=\"https:\/\/www.pavlatou.gr\/en\/congenital-adrenal-hyperplasia\/#symptwmata\" >\n\t\t\t\t\t\t<span class=\"ux-menu-link__text\">\n\t\t\t\tWhat are the symptoms and signs of the disease?\t\t\t<\/span>\n\t\t<\/a>\n\t<\/div>\n\t\n\t<div class=\"ux-menu-link flex menu-item first-menu-item\">\n\t\t<a class=\"ux-menu-link__link flex\" href=\"https:\/\/www.pavlatou.gr\/en\/congenital-adrenal-hyperplasia\/#epiplokes\" >\n\t\t\t\t\t\t<span class=\"ux-menu-link__text\">\n\t\t\t\tWhat are the complications of congenital adrenal hyperplasia?\t\t\t<\/span>\n\t\t<\/a>\n\t<\/div>\n\t\n\t<div class=\"ux-menu-link flex menu-item first-menu-item\">\n\t\t<a class=\"ux-menu-link__link flex\" href=\"https:\/\/www.pavlatou.gr\/en\/congenital-adrenal-hyperplasia\/#diagnosi\" >\n\t\t\t\t\t\t<span class=\"ux-menu-link__text\">\n\t\t\t\tHow is congenital adrenal hyperplasia diagnosed?\t\t\t<\/span>\n\t\t<\/a>\n\t<\/div>\n\t\n\t<div class=\"ux-menu-link flex menu-item first-menu-item\">\n\t\t<a class=\"ux-menu-link__link flex\" href=\"https:\/\/www.pavlatou.gr\/en\/congenital-adrenal-hyperplasia\/#therapeia\" >\n\t\t\t\t\t\t<span class=\"ux-menu-link__text\">\n\t\t\t\tHow is congenital adrenal hyperplasia treated?\t\t\t<\/span>\n\t\t<\/a>\n\t<\/div>\n\t\n\t<\/div>\n\t\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\n\t\n\n\t<div id=\"col-436630584\" class=\"col medium-8 small-12 large-8\"  >\n\t\t\t\t<div class=\"col-inner\"  >\n\t\t\t\n\t\t\t\n<h2 id=\"ti-einai\" style=\"font-size: 20px;\">What is Congenital Adrenal Hyperplasia?<\/h2>\n<div class=\"is-divider divider clearfix\" style=\"max-width:30%;background-color:rgb(155, 0, 128);\"><\/div>\n\t<div id=\"gap-330087424\" class=\"gap-element clearfix\" style=\"display:block; height:auto;\">\n\t\t\n<style>\n#gap-330087424 {\n  padding-top: 20px;\n}\n<\/style>\n\t<\/div>\n\t\n<p>Congenital <a href=\"https:\/\/www.pavlatou.gr\/en\/epinefridia\/\">adrenal<\/a> hyperplasia is a genetic condition that leads to a lack of the enzyme responsible for the final stage in the synthesis of cortisol by the adrenal glands. The result is inadequate production of cortisol and aldosterone and overproduction of androgens.<\/p>\n<a href=\"https:\/\/www.pavlatou.gr\/en\/congenital-adrenal-hyperplasia\/#ti-einai\" class=\"button secondary is-link is-xsmall lowercase\"  >\n    <span>Top<\/span>\n  <i class=\"icon-angle-right\" aria-hidden=\"true\" ><\/i><\/a>\n\n\t<div id=\"gap-1596577216\" class=\"gap-element clearfix\" style=\"display:block; height:auto;\">\n\t\t\n<style>\n#gap-1596577216 {\n  padding-top: 50px;\n}\n<\/style>\n\t<\/div>\n\t\n<h2 id=\"aitia\" style=\"font-size: 20px;\">What is the cause of congenital adrenal hyperplasia?<\/h2>\n<div class=\"is-divider divider clearfix\" style=\"max-width:30%;background-color:rgb(155, 0, 128);\"><\/div>\n\t<div id=\"gap-1707510430\" class=\"gap-element clearfix\" style=\"display:block; height:auto;\">\n\t\t\n<style>\n#gap-1707510430 {\n  padding-top: 20px;\n}\n<\/style>\n\t<\/div>\n\t\n<p>The cause of congenital adrenal hyperplasia is a mutation in the gene that synthesises the enzyme responsible for the synthesis of cortisol. Depending on the severity of the mutation, the disease may occur at birth (<strong>Classic form<\/strong>) or later in young adulthood (<strong>Non-Classical form<\/strong>).<\/p>\n<a href=\"https:\/\/www.pavlatou.gr\/en\/congenital-adrenal-hyperplasia\/#ti-einai\" class=\"button secondary is-link is-xsmall lowercase\"  >\n    <span>Top<\/span>\n  <i class=\"icon-angle-right\" aria-hidden=\"true\" ><\/i><\/a>\n\n\t<div id=\"gap-1536696540\" class=\"gap-element clearfix\" style=\"display:block; height:auto;\">\n\t\t\n<style>\n#gap-1536696540 {\n  padding-top: 50px;\n}\n<\/style>\n\t<\/div>\n\t\n<h2 id=\"klhronomikothta\" style=\"font-size: 20px;\">If I have the disease, will I pass it on to my child?<\/h2>\n<div class=\"is-divider divider clearfix\" style=\"max-width:30%;background-color:rgb(155, 0, 128);\"><\/div>\n\t<div id=\"gap-1448377211\" class=\"gap-element clearfix\" style=\"display:block; height:auto;\">\n\t\t\n<style>\n#gap-1448377211 {\n  padding-top: 20px;\n}\n<\/style>\n\t<\/div>\n\t\n<p>Congenital adrenal hyperplasia is inherited by an autosomal recessive pattern of inheritance, which means that for a child to develop the disease he or she must inherit the mutation from both parents. Because the severity of the mutation differs in the two forms of the disease, <u>genetic counselling is essential.<\/u><\/p>\n<a href=\"https:\/\/www.pavlatou.gr\/en\/congenital-adrenal-hyperplasia\/#ti-einai\" class=\"button secondary is-link is-xsmall lowercase\"  >\n    <span>Top<\/span>\n  <i class=\"icon-angle-right\" aria-hidden=\"true\" ><\/i><\/a>\n\n\t<div id=\"gap-233027373\" class=\"gap-element clearfix\" style=\"display:block; height:auto;\">\n\t\t\n<style>\n#gap-233027373 {\n  padding-top: 50px;\n}\n<\/style>\n\t<\/div>\n\t\n<h2 id=\"syxnothta\" style=\"font-size: 20px;\">What is the incidence of the disease?<\/h2>\n<div class=\"is-divider divider clearfix\" style=\"max-width:30%;background-color:rgb(155, 0, 128);\"><\/div>\n<p>The incidence of the disease is 1 in 15000 births.<\/p>\n<a href=\"https:\/\/www.pavlatou.gr\/en\/congenital-adrenal-hyperplasia\/#ti-einai\" class=\"button secondary is-link is-xsmall lowercase\"  >\n    <span>Top<\/span>\n  <i class=\"icon-angle-right\" aria-hidden=\"true\" ><\/i><\/a>\n\n\t<div id=\"gap-539209357\" class=\"gap-element clearfix\" style=\"display:block; height:auto;\">\n\t\t\n<style>\n#gap-539209357 {\n  padding-top: 50px;\n}\n<\/style>\n\t<\/div>\n\t\n<h2 id=\"symptwmata\" style=\"font-size: 20px;\">What are the symptoms and signs of the disease?<\/h2>\n<div class=\"is-divider divider clearfix\" style=\"max-width:30%;background-color:rgb(155, 0, 128);\"><\/div>\n\t<div id=\"gap-907886393\" class=\"gap-element clearfix\" style=\"display:block; height:auto;\">\n\t\t\n<style>\n#gap-907886393 {\n  padding-top: 20px;\n}\n<\/style>\n\t<\/div>\n\t\n<p>The symptoms and signs of the disease depend on the severity of the mutation and therefore the age of onset of the disease.<\/p>\n<ul>\n<li>Ambiguous genitalia<\/li>\n<li>Virilization of female infants<\/li>\n<li>Nausea, Vomiting<\/li>\n<li>Electrolyte Abnormalities<\/li>\n<li>Anorexia<\/li>\n<li>Weight loss<\/li>\n<li>Failure to thrive<\/li>\n<li>Precocious puberty<\/li>\n<li>Short stature<\/li>\n<li>Acne<\/li>\n<li>Hirsutism<\/li>\n<li><a href=\"https:\/\/www.pavlatou.gr\/en\/diataraxes-tou-kuklou\/\">Menstrual abnormalities<\/a><\/li>\n<li><a href=\"https:\/\/www.pavlatou.gr\/en\/ypogonimothta\/\">Infertility<\/a><\/li>\n<\/ul>\n<a href=\"https:\/\/www.pavlatou.gr\/en\/congenital-adrenal-hyperplasia\/#ti-einai\" class=\"button secondary is-link is-xsmall lowercase\"  >\n    <span>Top<\/span>\n  <i class=\"icon-angle-right\" aria-hidden=\"true\" ><\/i><\/a>\n\n\t<div id=\"gap-1956689030\" class=\"gap-element clearfix\" style=\"display:block; height:auto;\">\n\t\t\n<style>\n#gap-1956689030 {\n  padding-top: 50px;\n}\n<\/style>\n\t<\/div>\n\t\n<p><img fetchpriority=\"high\" decoding=\"async\" class=\"alignnone size-medium wp-image-3080\" src=\"https:\/\/www.pavlatou.gr\/wp-content\/uploads\/2021\/03\/kidneys-711x400.jpg\" alt=\"\u039d\u03b5\u03c6\u03c1\u03ac \u03b5\u03c0\u03b9\u03bd\u03b5\u03c6\u03c1\u03af\u03b4\u03b9\u03b1 - \u03a3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf Cushing - \u03c0\u03c1\u03c9\u03c4\u03bf\u03c0\u03b1\u03b8\u03ae\u03c2 \u03c5\u03c0\u03b5\u03c1\u03b1\u03bb\u03b4\u03bf\u03c3\u03c4\u03b5\u03c1\u03bf\u03bd\u03b9\u03c3\u03bc\u03cc\u03c2 - \u03c4\u03c5\u03c7\u03b1\u03af\u03c9\u03bc\u03b1 \u03b5\u03c0\u03b9\u03bd\u03b5\u03c6\u03c1\u03b9\u03b4\u03af\u03c9\u03bd - \u03a3\u03c5\u03b3\u03b3\u03b5\u03bd\u03ae\u03c2 \u03c5\u03c0\u03b5\u03c1\u03c0\u03bb\u03b1\u03c3\u03af\u03b1 \u03c4\u03c9\u03bd \u03b5\u03c0\u03b9\u03bd\u03b5\u03c6\u03c1\u03b9\u03b4\u03af\u03c9\u03bd\" width=\"711\" height=\"400\" srcset=\"https:\/\/www.pavlatou.gr\/wp-content\/uploads\/2021\/03\/kidneys-711x400.jpg 711w, https:\/\/www.pavlatou.gr\/wp-content\/uploads\/2021\/03\/kidneys-768x432.jpg 768w, https:\/\/www.pavlatou.gr\/wp-content\/uploads\/2021\/03\/kidneys.jpg 1070w\" sizes=\"(max-width: 711px) 100vw, 711px\" \/><\/p>\n\t<div id=\"gap-682879197\" class=\"gap-element clearfix\" style=\"display:block; height:auto;\">\n\t\t\n<style>\n#gap-682879197 {\n  padding-top: 50px;\n}\n<\/style>\n\t<\/div>\n\t\n<h2 id=\"epiplokes\" style=\"font-size: 20px;\">What are the complications of congenital adrenal hyperplasia?<\/h2>\n<div class=\"is-divider divider clearfix\" style=\"max-width:30%;background-color:rgb(155, 0, 128);\"><\/div>\n\t<div id=\"gap-932799939\" class=\"gap-element clearfix\" style=\"display:block; height:auto;\">\n\t\t\n<style>\n#gap-932799939 {\n  padding-top: 20px;\n}\n<\/style>\n\t<\/div>\n\t\n<ul>\n<li>Salt wasting<\/li>\n<li>Dehydration<\/li>\n<li>Adrenal crisis<\/li>\n<li>Hypovolemic shock<\/li>\n<li>Death<\/li>\n<li>Adrenal tumors<\/li>\n<li>Ectopic adrenal tissue in the testes<\/li>\n<li><a href=\"https:\/\/www.pavlatou.gr\/en\/endokrinikh-ypertash\/\">Hypertension<\/a><\/li>\n<li>Metabolic Syndrome<\/li>\n<li>Infertility<\/li>\n<\/ul>\n<a href=\"https:\/\/www.pavlatou.gr\/en\/congenital-adrenal-hyperplasia\/#ti-einai\" class=\"button secondary is-link is-xsmall lowercase\"  >\n    <span>Top<\/span>\n  <i class=\"icon-angle-right\" aria-hidden=\"true\" ><\/i><\/a>\n\n\t<div id=\"gap-1874982377\" class=\"gap-element clearfix\" style=\"display:block; height:auto;\">\n\t\t\n<style>\n#gap-1874982377 {\n  padding-top: 50px;\n}\n<\/style>\n\t<\/div>\n\t\n<h2 id=\"diagnosi\" style=\"font-size: 20px;\">How is congenital adrenal hyperplasia diagnosed?<\/h2>\n<div class=\"is-divider divider clearfix\" style=\"max-width:30%;background-color:rgb(155, 0, 128);\"><\/div>\n\t<div id=\"gap-514376587\" class=\"gap-element clearfix\" style=\"display:block; height:auto;\">\n\t\t\n<style>\n#gap-514376587 {\n  padding-top: 20px;\n}\n<\/style>\n\t<\/div>\n\t\n<p>The diagnosis of congenital adrenal hyperplasia is made by a combination of history, clinical examination, hormonal, imaging and genetic testing. Screening for congenital adrenal hyperplasia is included in the neonatal screening programme in several countries. Either positive results in screening, clinical indications or doubtful results are followed by biochemical confirmation which may include specific endocrine tests. Confirmation of the disease is done by genetic testing and mutation detection. Diagnosis may also be made prenatally in specialised centres.<\/p>\n<a href=\"https:\/\/www.pavlatou.gr\/en\/congenital-adrenal-hyperplasia\/#ti-einai\" class=\"button secondary is-link is-xsmall lowercase\"  >\n    <span>Top<\/span>\n  <i class=\"icon-angle-right\" aria-hidden=\"true\" ><\/i><\/a>\n\n\t<div id=\"gap-945966696\" class=\"gap-element clearfix\" style=\"display:block; height:auto;\">\n\t\t\n<style>\n#gap-945966696 {\n  padding-top: 50px;\n}\n<\/style>\n\t<\/div>\n\t\n<h2 id=\"therapeia\" style=\"font-size: 20px;\">How is congenital adrenal hyperplasia treated?<\/h2>\n<div class=\"is-divider divider clearfix\" style=\"max-width:30%;background-color:rgb(155, 0, 128);\"><\/div>\n\t<div id=\"gap-1250072870\" class=\"gap-element clearfix\" style=\"display:block; height:auto;\">\n\t\t\n<style>\n#gap-1250072870 {\n  padding-top: 20px;\n}\n<\/style>\n\t<\/div>\n\t\n<p>Depending on the severity of the mutation and the age at diagnosis, treatment aims to prevent adrenal crisis, optimize growth and reproductive function. This is achieved by replacing the insufficient hormones and surgical repair of the external genitalia where necessary. Psychological support and <em>genetic counselling<\/em> from <em>puberty<\/em> onwards is also essential. <em>Regular monitoring<\/em> of patients is vital.<\/p>\n<a href=\"https:\/\/www.pavlatou.gr\/en\/congenital-adrenal-hyperplasia\/#ti-einai\" class=\"button secondary is-link is-xsmall lowercase\"  >\n    <span>Top<\/span>\n  <i class=\"icon-angle-right\" aria-hidden=\"true\" ><\/i><\/a>\n\n\t<div id=\"gap-624835159\" class=\"gap-element clearfix\" style=\"display:block; height:auto;\">\n\t\t\n<style>\n#gap-624835159 {\n  padding-top: 50px;\n}\n<\/style>\n\t<\/div>\n\t\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\n\t\n<\/div>\n\t\t<\/div>\n\n\t\t\n<style>\n#section_669181423 {\n  padding-top: 30px;\n  padding-bottom: 30px;\n}\n<\/style>\n\t<\/section>\n\t\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":5,"featured_media":0,"parent":0,"menu_order":437,"comment_status":"closed","ping_status":"closed","template":"page-blank.php","meta":{"footnotes":""},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.1 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Information about congenital adrenal hyperplasia from Dr. Maria Pavlatou|<\/title>\n<meta name=\"description\" content=\"Treatment of congenital adrenal hyperplasia by the experienced endocrinologist-diabetologist Dr. Maria Pavlatou.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pavlatou.gr\/en\/congenital-adrenal-hyperplasia\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" 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