{"id":5317,"date":"2021-04-01T13:34:50","date_gmt":"2021-04-01T13:34:50","guid":{"rendered":"https:\/\/www.pavlatou.gr\/?page_id=5317"},"modified":"2024-04-15T14:00:55","modified_gmt":"2024-04-15T14:00:55","slug":"men1","status":"publish","type":"page","link":"https:\/\/www.pavlatou.gr\/en\/men1\/","title":{"rendered":"Multiple Endocrine Neoplasia Syndrome 1 (Men1)"},"content":{"rendered":"\t<section class=\"section\" id=\"section_1528660944\">\n\t\t<div class=\"bg section-bg fill bg-fill  bg-loaded\" >\n\n\t\t\t\n\t\t\t\n\t\t\t\n\n\t\t<\/div>\n\n\t\t\n\n\t\t<div class=\"section-content relative\">\n\t\t\t\n\n  <div class=\"banner has-hover\" id=\"banner-831099019\">\n          <div class=\"banner-inner fill\">\n        <div class=\"banner-bg fill\" >\n            <div class=\"bg fill bg-fill \"><\/div>\n                        <div class=\"overlay\"><\/div>            \n                    <\/div>\n\t\t\n        <div class=\"banner-layers container\">\n            <div class=\"fill banner-link\"><\/div>            \n   <div id=\"text-box-1221104074\" class=\"text-box banner-layer x0 md-x0 lg-x0 y50 md-y50 lg-y50 res-text\">\n                                <div class=\"text-box-content text dark\">\n              \n              <div class=\"text-inner text-left\">\n                  \n\t<div id=\"text-1227004000\" class=\"text\">\n\t\t\n<h3>MULTIPLE ENDOCRINE NEOPLASIA SYNDROME 1 (MEN1)<\/h3>\n<p>MEN1 syndrome is characterized by the occurrence of multiple endocrine tumours that are hereditary<\/p>\n\t\t\n<style>\n#text-1227004000 {\n  color: rgb(0, 0, 0);\n}\n#text-1227004000 > * {\n  color: rgb(0, 0, 0);\n}\n<\/style>\n\t<\/div>\n\t\n              <\/div>\n           <\/div>\n                            \n<style>\n#text-box-1221104074 .text-box-content {\n  background-color: rgba(255, 255, 255, 0.16);\n  font-size: 100%;\n}\n#text-box-1221104074 .text-inner {\n  padding: 0px 0px 0px 20px;\n}\n#text-box-1221104074 {\n  width: 60%;\n}\n<\/style>\n    <\/div>\n \n        <\/div>\n      <\/div>\n\n            \n<style>\n#banner-831099019 {\n  padding-top: 600px;\n}\n#banner-831099019 .bg.bg-loaded {\n  background-image: url(https:\/\/www.pavlatou.gr\/wp-content\/uploads\/2024\/04\/medical-563427_1280-1200x800.jpg);\n}\n#banner-831099019 .overlay {\n  background-color: rgba(0, 0, 0, 0.17);\n}\n<\/style>\n  <\/div>\n\n\n\t\t<\/div>\n\n\t\t\n<style>\n#section_1528660944 {\n  padding-top: 30px;\n  padding-bottom: 30px;\n}\n<\/style>\n\t<\/section>\n\t\n\t<section class=\"section\" id=\"section_240457633\">\n\t\t<div class=\"bg section-bg fill bg-fill  bg-loaded\" >\n\n\t\t\t\n\t\t\t\n\t\t\t\n\n\t\t<\/div>\n\n\t\t\n\n\t\t<div class=\"section-content relative\">\n\t\t\t\n<div class=\"row\"  id=\"row-1655038130\">\n\n\t<div id=\"col-733536573\" class=\"col medium-3 small-12 large-3 col-divided\"  >\n\t\t\t\t<div class=\"col-inner text-left\"  >\n\t\t\t\n\t\t\t\n\t<div class=\"ux-menu stack stack-col justify-start ux-menu--divider-solid\">\n\t\t\n\t<div class=\"ux-menu-link flex menu-item first-menu-item\">\n\t\t<a class=\"ux-menu-link__link flex\" href=\"https:\/\/www.pavlatou.gr\/en\/men1\/#ti-einai\" >\n\t\t\t\t\t\t<span class=\"ux-menu-link__text\">\n\t\t\t\tWhat is Multiple Endocrine Neoplasia Syndrome 1 (MEN1)?\t\t\t<\/span>\n\t\t<\/a>\n\t<\/div>\n\t\n\t<div class=\"ux-menu-link flex menu-item first-menu-item\">\n\t\t<a class=\"ux-menu-link__link flex\" href=\"https:\/\/www.pavlatou.gr\/en\/men1\/#syxnothta\" >\n\t\t\t\t\t\t<span class=\"ux-menu-link__text\">\n\t\t\t\tHow common is MEN1 syndrome and how is it inherited?\t\t\t<\/span>\n\t\t<\/a>\n\t<\/div>\n\t\n\t<div class=\"ux-menu-link flex menu-item first-menu-item\">\n\t\t<a class=\"ux-menu-link__link flex\" href=\"https:\/\/www.pavlatou.gr\/en\/men1\/#ekdilwsi\" >\n\t\t\t\t\t\t<span class=\"ux-menu-link__text\">\n\t\t\t\tHow does MEN1 syndrome present and at what age do the tumours develop?\t\t\t<\/span>\n\t\t<\/a>\n\t<\/div>\n\t\n\t<div class=\"ux-menu-link flex menu-item first-menu-item\">\n\t\t<a class=\"ux-menu-link__link flex\" href=\"https:\/\/www.pavlatou.gr\/en\/men1\/#kindynos-kakoithias\" >\n\t\t\t\t\t\t<span class=\"ux-menu-link__text\">\n\t\t\t\tIs there an increased risk of malignancy?\t\t\t<\/span>\n\t\t<\/a>\n\t<\/div>\n\t\n\t<div class=\"ux-menu-link flex menu-item first-menu-item\">\n\t\t<a class=\"ux-menu-link__link flex\" href=\"https:\/\/www.pavlatou.gr\/en\/men1\/#foreis\" >\n\t\t\t\t\t\t<span class=\"ux-menu-link__text\">\n\t\t\t\tWhat should carriers do?\t\t\t<\/span>\n\t\t<\/a>\n\t<\/div>\n\t\n\t<\/div>\n\t\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\n\t\n\n\t<div id=\"col-857328703\" class=\"col medium-8 small-12 large-8\"  >\n\t\t\t\t<div class=\"col-inner\"  >\n\t\t\t\n\t\t\t\n<h2 id=\"ti-einai\" style=\"font-size: 20px;\">What is Multiple Endocrine Neoplasia Syndrome 1 (MEN1)?<\/h2>\n<div class=\"is-divider divider clearfix\" style=\"max-width:30%;background-color:rgb(155, 0, 128);\"><\/div>\n\t<div id=\"gap-1690872673\" class=\"gap-element clearfix\" style=\"display:block; height:auto;\">\n\t\t\n<style>\n#gap-1690872673 {\n  padding-top: 20px;\n}\n<\/style>\n\t<\/div>\n\t\n<p>MEN1 syndrome is caused by mutations in the MEN1 gene, which deactivates or disrupts the function of the tumour-suppressor protein menin, resulting in multiple endocrine and non- endocrine tumours.<\/p>\n<a href=\"https:\/\/www.pavlatou.gr\/en\/men1\/#ti-einai\" class=\"button secondary is-link is-xsmall lowercase\"  >\n    <span>Top<\/span>\n  <i class=\"icon-angle-right\" aria-hidden=\"true\" ><\/i><\/a>\n\n\t<div id=\"gap-303835\" class=\"gap-element clearfix\" style=\"display:block; height:auto;\">\n\t\t\n<style>\n#gap-303835 {\n  padding-top: 50px;\n}\n<\/style>\n\t<\/div>\n\t\n<h2 id=\"syxnothta\" style=\"font-size: 20px;\">How common is MEN1 syndrome and how is it inherited?<\/h2>\n<div class=\"is-divider divider clearfix\" style=\"max-width:30%;background-color:rgb(155, 0, 128);\"><\/div>\n\t<div id=\"gap-704101564\" class=\"gap-element clearfix\" style=\"display:block; height:auto;\">\n\t\t\n<style>\n#gap-704101564 {\n  padding-top: 20px;\n}\n<\/style>\n\t<\/div>\n\t\n<p>The prevalence of the disease is 2-20 per 100,000 in the general population and is inherited in an autosomal dominant pattern<\/p>\n<a href=\"https:\/\/www.pavlatou.gr\/en\/men1\/#ti-einai\" class=\"button secondary is-link is-xsmall lowercase\"  >\n    <span>Top<\/span>\n  <i class=\"icon-angle-right\" aria-hidden=\"true\" ><\/i><\/a>\n\n\t<div id=\"gap-964586608\" class=\"gap-element clearfix\" style=\"display:block; height:auto;\">\n\t\t\n<style>\n#gap-964586608 {\n  padding-top: 50px;\n}\n<\/style>\n\t<\/div>\n\t\n<h2 id=\"ekdilwsi\" style=\"font-size: 20px;\">How does MEN1 syndrome present and at what age do the tumours develop?<\/h2>\n<div class=\"is-divider divider clearfix\" style=\"max-width:30%;background-color:rgb(155, 0, 128);\"><\/div>\n\t<div id=\"gap-737181646\" class=\"gap-element clearfix\" style=\"display:block; height:auto;\">\n\t\t\n<style>\n#gap-737181646 {\n  padding-top: 20px;\n}\n<\/style>\n\t<\/div>\n\t\n<p>Carriers of the mutation develop:<\/p>\n<ul>\n<li>primary <a href=\"https:\/\/www.pavlatou.gr\/en\/yperparathyreoeidismos\/\">hyperparathyroidism<\/a> in 90% of cases<\/li>\n<li>Enteropancreatic tumours in 30-70% of cases<\/li>\n<li><a href=\"https:\/\/www.pavlatou.gr\/en\/ogkoi-ypofysis\/\">pituitary tumours<\/a> in 30-40% of cases<\/li>\n<li><a href=\"https:\/\/www.pavlatou.gr\/en\/adrenal-adenoma\/\">adrenocortical tumours<\/a> 40%<\/li>\n<li>pheochromocytomas &lt;1%<\/li>\n<li>facial angiofibromas 85%<\/li>\n<li>lipomas 30% and<\/li>\n<li>other tumours<\/li>\n<\/ul>\n<p>Such tumours develop much earlier than their corresponding sporadic tumours, with a youngest age of onset of 5 years and a peak age of 50 years.<\/p>\n<a href=\"https:\/\/www.pavlatou.gr\/en\/men1\/#ti-einai\" class=\"button secondary is-link is-xsmall lowercase\"  >\n    <span>Top<\/span>\n  <i class=\"icon-angle-right\" aria-hidden=\"true\" ><\/i><\/a>\n\n\t<div id=\"gap-207109164\" class=\"gap-element clearfix\" style=\"display:block; height:auto;\">\n\t\t\n<style>\n#gap-207109164 {\n  padding-top: 50px;\n}\n<\/style>\n\t<\/div>\n\t\n<h2 id=\"kindynos-kakoithias\" style=\"font-size: 20px;\">Is there an increased risk of malignancy?<\/h2>\n<div class=\"is-divider divider clearfix\" style=\"max-width:30%;background-color:rgb(155, 0, 128);\"><\/div>\n\t<div id=\"gap-346840590\" class=\"gap-element clearfix\" style=\"display:block; height:auto;\">\n\t\t\n<style>\n#gap-346840590 {\n  padding-top: 20px;\n}\n<\/style>\n\t<\/div>\n\t\n<p>Malignant <a href=\"https:\/\/www.pavlatou.gr\/en\/gep-net\/\">pancreatic neuroendocrine tumours (NETs),<\/a> and thymic carcinoma are the most common causes of death in these patients.<\/p>\n<a href=\"https:\/\/www.pavlatou.gr\/en\/men1\/#ti-einai\" class=\"button secondary is-link is-xsmall lowercase\"  >\n    <span>Top<\/span>\n  <i class=\"icon-angle-right\" aria-hidden=\"true\" ><\/i><\/a>\n\n\t<div id=\"gap-4688656\" class=\"gap-element clearfix\" style=\"display:block; height:auto;\">\n\t\t\n<style>\n#gap-4688656 {\n  padding-top: 50px;\n}\n<\/style>\n\t<\/div>\n\t\n<h2 id=\"foreis\" style=\"font-size: 20px;\">What should carriers do?<\/h2>\n<div class=\"is-divider divider clearfix\" style=\"max-width:30%;background-color:rgb(155, 0, 128);\"><\/div>\n\t<div id=\"gap-118252874\" class=\"gap-element clearfix\" style=\"display:block; height:auto;\">\n\t\t\n<style>\n#gap-118252874 {\n  padding-top: 20px;\n}\n<\/style>\n\t<\/div>\n\t\n<p>As these tumours, whether benign or malignant, increase the morbidity rate and sometimes reduce survival rates, regular monitoring is mandatory for immediate intervention when and where needed.<\/p>\n<a href=\"https:\/\/www.pavlatou.gr\/en\/men1\/#ti-einai\" class=\"button secondary is-link is-xsmall lowercase\"  >\n    <span>Top<\/span>\n  <i class=\"icon-angle-right\" aria-hidden=\"true\" ><\/i><\/a>\n\n\t<div id=\"gap-972159976\" class=\"gap-element clearfix\" style=\"display:block; height:auto;\">\n\t\t\n<style>\n#gap-972159976 {\n  padding-top: 20px;\n}\n<\/style>\n\t<\/div>\n\t\n\t<div id=\"gap-1829167218\" class=\"gap-element clearfix\" style=\"display:block; height:auto;\">\n\t\t\n<style>\n#gap-1829167218 {\n  padding-top: 50px;\n}\n<\/style>\n\t<\/div>\n\t\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\n\t\n<\/div>\n\t\t<\/div>\n\n\t\t\n<style>\n#section_240457633 {\n  padding-top: 30px;\n  padding-bottom: 30px;\n}\n<\/style>\n\t<\/section>\n\t\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":5,"featured_media":0,"parent":0,"menu_order":554,"comment_status":"closed","ping_status":"closed","template":"page-blank.php","meta":{"footnotes":""},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.1 - 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