{"id":5311,"date":"2021-04-01T13:25:35","date_gmt":"2021-04-01T13:25:35","guid":{"rendered":"https:\/\/www.pavlatou.gr\/?page_id=5311"},"modified":"2024-04-15T13:57:36","modified_gmt":"2024-04-15T13:57:36","slug":"men2","status":"publish","type":"page","link":"https:\/\/www.pavlatou.gr\/en\/men2\/","title":{"rendered":"Multiple Endocrine Neoplasia Syndrome 2 (Men2)"},"content":{"rendered":"\t<section class=\"section\" id=\"section_982212803\">\n\t\t<div class=\"bg section-bg fill bg-fill  bg-loaded\" >\n\n\t\t\t\n\t\t\t\n\t\t\t\n\n\t\t<\/div>\n\n\t\t\n\n\t\t<div class=\"section-content relative\">\n\t\t\t\n\n  <div class=\"banner has-hover\" id=\"banner-2058522854\">\n          <div class=\"banner-inner fill\">\n        <div class=\"banner-bg fill\" >\n            <div class=\"bg fill bg-fill \"><\/div>\n                        <div class=\"overlay\"><\/div>            \n                    <\/div>\n\t\t\n        <div class=\"banner-layers container\">\n            <div class=\"fill banner-link\"><\/div>            \n   <div id=\"text-box-905012510\" class=\"text-box banner-layer x0 md-x0 lg-x0 y50 md-y50 lg-y50 res-text\">\n                                <div class=\"text-box-content text dark\">\n              \n              <div class=\"text-inner text-left\">\n                  \n\t<div id=\"text-2426393052\" class=\"text\">\n\t\t\n<h3>MULTIPLE ENDOCRINE NEOPLASIA SYNDROME 2 (MEN2)<\/h3>\n<p>MEN2 syndrome is characterised by the occurrence of multiple endocrine tumours that are hereditary<\/p>\n\t\t\n<style>\n#text-2426393052 {\n  color: rgb(255, 255, 255);\n}\n#text-2426393052 > * {\n  color: rgb(255, 255, 255);\n}\n<\/style>\n\t<\/div>\n\t\n              <\/div>\n           <\/div>\n                            \n<style>\n#text-box-905012510 .text-box-content {\n  background-color: rgba(255, 255, 255, 0.16);\n  font-size: 100%;\n}\n#text-box-905012510 .text-inner {\n  padding: 0px 0px 0px 20px;\n}\n#text-box-905012510 {\n  width: 60%;\n}\n<\/style>\n    <\/div>\n \n        <\/div>\n      <\/div>\n\n            \n<style>\n#banner-2058522854 {\n  padding-top: 600px;\n}\n#banner-2058522854 .bg.bg-loaded {\n  background-image: url(https:\/\/www.pavlatou.gr\/wp-content\/uploads\/2024\/04\/hush-naidoo-jade-photography-yo01Z-9HQAw-unsplash-1200x800.jpg);\n}\n#banner-2058522854 .overlay {\n  background-color: rgba(0, 0, 0, 0.17);\n}\n<\/style>\n  <\/div>\n\n\n\t\t<\/div>\n\n\t\t\n<style>\n#section_982212803 {\n  padding-top: 30px;\n  padding-bottom: 30px;\n}\n<\/style>\n\t<\/section>\n\t\n\t<section class=\"section\" id=\"section_1874895614\">\n\t\t<div class=\"bg section-bg fill bg-fill  bg-loaded\" >\n\n\t\t\t\n\t\t\t\n\t\t\t\n\n\t\t<\/div>\n\n\t\t\n\n\t\t<div class=\"section-content relative\">\n\t\t\t\n<div class=\"row\"  id=\"row-1991640247\">\n\n\t<div id=\"col-1354137265\" class=\"col medium-3 small-12 large-3 col-divided\"  >\n\t\t\t\t<div class=\"col-inner text-left\"  >\n\t\t\t\n\t\t\t\n\t<div class=\"ux-menu stack stack-col justify-start ux-menu--divider-solid\">\n\t\t\n\t<div class=\"ux-menu-link flex menu-item first-menu-item\">\n\t\t<a class=\"ux-menu-link__link flex\" href=\"https:\/\/www.pavlatou.gr\/en\/men2\/#ti-einai\" >\n\t\t\t\t\t\t<span class=\"ux-menu-link__text\">\n\t\t\t\tWhat is Multiple Endocrine Neoplasia Syndrome 2 (MEN2) and how is it inherited?\t\t\t<\/span>\n\t\t<\/a>\n\t<\/div>\n\t\n\t<div class=\"ux-menu-link flex menu-item first-menu-item\">\n\t\t<a class=\"ux-menu-link__link flex\" href=\"https:\/\/www.pavlatou.gr\/en\/men2\/#ekdilwsi\" >\n\t\t\t\t\t\t<span class=\"ux-menu-link__text\">\n\t\t\t\tHow does MEN2 syndrome present and what percentage develops malignancy?\t\t\t<\/span>\n\t\t<\/a>\n\t<\/div>\n\t\n\t<div class=\"ux-menu-link flex menu-item first-menu-item\">\n\t\t<a class=\"ux-menu-link__link flex\" href=\"https:\/\/www.pavlatou.gr\/en\/men2\/#syxnothta\" >\n\t\t\t\t\t\t<span class=\"ux-menu-link__text\">\n\t\t\t\tHow common is MEN2 syndrome and at what age does pheochromocytoma develop?\t\t\t<\/span>\n\t\t<\/a>\n\t<\/div>\n\t\n\t<div class=\"ux-menu-link flex menu-item first-menu-item\">\n\t\t<a class=\"ux-menu-link__link flex\" href=\"https:\/\/www.pavlatou.gr\/en\/men2\/#foreis\" >\n\t\t\t\t\t\t<span class=\"ux-menu-link__text\">\n\t\t\t\tWhat should carriers do?\t\t\t<\/span>\n\t\t<\/a>\n\t<\/div>\n\t\n\t<\/div>\n\t\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\n\t\n\n\t<div id=\"col-552807621\" class=\"col medium-8 small-12 large-8\"  >\n\t\t\t\t<div class=\"col-inner\"  >\n\t\t\t\n\t\t\t\n<h2 id=\"ti-einai\" style=\"font-size: 20px;\">What is Multiple Endocrine Neoplasia Syndrome 2 (MEN2) and how is it inherited?<\/h2>\n<div class=\"is-divider divider clearfix\" style=\"max-width:30%;background-color:rgb(155, 0, 128);\"><\/div>\n\t<div id=\"gap-1225439743\" class=\"gap-element clearfix\" style=\"display:block; height:auto;\">\n\t\t\n<style>\n#gap-1225439743 {\n  padding-top: 20px;\n}\n<\/style>\n\t<\/div>\n\t\n<p>MEN2 syndrome is inherited in an autosomal dominant pattern, and is caused by activating mutations in the RET proto-oncogene leading to the development of multiple endocrine tumours.<\/p>\n<a href=\"https:\/\/www.pavlatou.gr\/en\/men2\/#ti-einai\" class=\"button secondary is-link is-xsmall lowercase\"  >\n    <span>Top<\/span>\n  <i class=\"icon-angle-right\" aria-hidden=\"true\" ><\/i><\/a>\n\n\t<div id=\"gap-89795497\" class=\"gap-element clearfix\" style=\"display:block; height:auto;\">\n\t\t\n<style>\n#gap-89795497 {\n  padding-top: 50px;\n}\n<\/style>\n\t<\/div>\n\t\n<h2 id=\"ekdilwsi\" style=\"font-size: 20px;\">How does MEN2 syndrome present and what percentage develops malignancy?<\/h2>\n<div class=\"is-divider divider clearfix\" style=\"max-width:30%;background-color:rgb(155, 0, 128);\"><\/div>\n\t<div id=\"gap-1516484891\" class=\"gap-element clearfix\" style=\"display:block; height:auto;\">\n\t\t\n<style>\n#gap-1516484891 {\n  padding-top: 20px;\n}\n<\/style>\n\t<\/div>\n\t\n<p>The syndrome is divided into MEN2A, where patients develop:<\/p>\n<ul>\n<li>Medullary thyroid cancer in 95-100% of cases<\/li>\n<li>primary hyperparathyroidism, due to hyperplasia of multiple parathyroid glands (20%) and<\/li>\n<li>pheochromocytoma, in a percentage ranging from 60-100%<\/li>\n<\/ul>\n<p>and in MEN2B characterized by growth of:<\/p>\n<ul>\n<li>aggressive medullary thyroid cancer, in almost all patients<\/li>\n<li>pheochromocytoma in half of the patients<\/li>\n<li>mucosal neuromas and intestinal ganglioneuromas<\/li>\n<li>skeletal deformities and<\/li>\n<li>characteristic facial features<\/li>\n<\/ul>\n<a href=\"https:\/\/www.pavlatou.gr\/en\/men2\/#ti-einai\" class=\"button secondary is-link is-xsmall lowercase\"  >\n    <span>Top<\/span>\n  <i class=\"icon-angle-right\" aria-hidden=\"true\" ><\/i><\/a>\n\n\t<div id=\"gap-900993952\" class=\"gap-element clearfix\" style=\"display:block; height:auto;\">\n\t\t\n<style>\n#gap-900993952 {\n  padding-top: 50px;\n}\n<\/style>\n\t<\/div>\n\t\n<h2 id=\"syxnothta\" style=\"font-size: 20px;\">How common is MEN2 syndrome and at what age does pheochromocytoma develop?<\/h2>\n<div class=\"is-divider divider clearfix\" style=\"max-width:30%;background-color:rgb(155, 0, 128);\"><\/div>\n\t<div id=\"gap-678259003\" class=\"gap-element clearfix\" style=\"display:block; height:auto;\">\n\t\t\n<style>\n#gap-678259003 {\n  padding-top: 20px;\n}\n<\/style>\n\t<\/div>\n\t\n<p>The incidence of the disease is 1 in 30,000 people. Depending on the mutation, pheochromocytoma can occur from the age of 8 with an average age, the age of 30. The majority of patients will develop pheochromocytoma in the other adrenal gland within a decade.<\/p>\n<a href=\"https:\/\/www.pavlatou.gr\/en\/men2\/#ti-einai\" class=\"button secondary is-link is-xsmall lowercase\"  >\n    <span>Top<\/span>\n  <i class=\"icon-angle-right\" aria-hidden=\"true\" ><\/i><\/a>\n\n\t<div id=\"gap-1310471253\" class=\"gap-element clearfix\" style=\"display:block; height:auto;\">\n\t\t\n<style>\n#gap-1310471253 {\n  padding-top: 50px;\n}\n<\/style>\n\t<\/div>\n\t\n<h2 id=\"foreis\" style=\"font-size: 20px;\">What should carriers do?<\/h2>\n<div class=\"is-divider divider clearfix\" style=\"max-width:30%;background-color:rgb(155, 0, 128);\"><\/div>\n\t<div id=\"gap-76259146\" class=\"gap-element clearfix\" style=\"display:block; height:auto;\">\n\t\t\n<style>\n#gap-76259146 {\n  padding-top: 20px;\n}\n<\/style>\n\t<\/div>\n\t\n<p>As medullary thyroid cancer can develop very early and is potentially life-threatening, <u>prophylactic total thyroidectomy is recommended in the first months of life in new-borns<\/u> with a confirmed mutation for MEN2B and in the first 5 years of life for MEN2A. In addition, as in other genetic syndromes, regular monitoring is mandatory.<\/p>\n<a href=\"https:\/\/www.pavlatou.gr\/en\/men2\/#ti-einai\" class=\"button secondary is-link is-xsmall lowercase\"  >\n    <span>Top<\/span>\n  <i class=\"icon-angle-right\" aria-hidden=\"true\" ><\/i><\/a>\n\n\t<div id=\"gap-1628551030\" class=\"gap-element clearfix\" style=\"display:block; height:auto;\">\n\t\t\n<style>\n#gap-1628551030 {\n  padding-top: 20px;\n}\n<\/style>\n\t<\/div>\n\t\n\t<div id=\"gap-336612642\" class=\"gap-element clearfix\" style=\"display:block; height:auto;\">\n\t\t\n<style>\n#gap-336612642 {\n  padding-top: 50px;\n}\n<\/style>\n\t<\/div>\n\t\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\n\t\n<\/div>\n\t\t<\/div>\n\n\t\t\n<style>\n#section_1874895614 {\n  padding-top: 30px;\n  padding-bottom: 30px;\n}\n<\/style>\n\t<\/section>\n\t\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":5,"featured_media":0,"parent":0,"menu_order":553,"comment_status":"closed","ping_status":"closed","template":"page-blank.php","meta":{"footnotes":""},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.1 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Multiple Endocrine Neoplasia Syndrome 2 (MEN2) and treatment |<\/title>\n<meta name=\"description\" content=\"Diagnosis and treatment of multiple endocrine neoplasia syndrome 2 (MEN2) by the experienced endocrinologist-diabetologist Dr. Maria Pavlatou.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pavlatou.gr\/en\/men2\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" 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