{"id":5263,"date":"2021-04-01T14:26:44","date_gmt":"2021-04-01T14:26:44","guid":{"rendered":"https:\/\/www.pavlatou.gr\/?page_id=5263"},"modified":"2024-04-23T11:10:15","modified_gmt":"2024-04-23T11:10:15","slug":"gep-net","status":"publish","type":"page","link":"https:\/\/www.pavlatou.gr\/en\/gep-net\/","title":{"rendered":"Neuroendocrine Tumours Of The Gastroenteropancreatic System"},"content":{"rendered":"\t<section class=\"section\" id=\"section_882494936\">\n\t\t<div class=\"bg section-bg fill bg-fill  bg-loaded\" >\n\n\t\t\t\n\t\t\t\n\t\t\t\n\n\t\t<\/div>\n\n\t\t\n\n\t\t<div class=\"section-content relative\">\n\t\t\t\n\n  <div class=\"banner has-hover\" id=\"banner-741848340\">\n          <div class=\"banner-inner fill\">\n        <div class=\"banner-bg fill\" >\n            <div class=\"bg fill bg-fill \"><\/div>\n                        <div class=\"overlay\"><\/div>            \n                    <\/div>\n\t\t\n        <div class=\"banner-layers container\">\n            <div class=\"fill banner-link\"><\/div>            \n   <div id=\"text-box-328657873\" class=\"text-box banner-layer x0 md-x0 lg-x0 y50 md-y50 lg-y50 res-text\">\n                                <div class=\"text-box-content text dark\">\n              \n              <div class=\"text-inner text-left\">\n                  \n\t<div id=\"text-892138462\" class=\"text\">\n\t\t\n<h3>NEUROENDOCRINE TUMOURS OF THE GASTROENTEROPANCREATIC SYSTEM (GEP-NET)<\/h3>\n<p>Tumours of the digestive system that originate from neuroendocrine cells are called Neuroendocrine Tumours of the GastrointestinalPancreaticSystem (GEP-NET).<\/p>\n\t\t\n<style>\n#text-892138462 {\n  color: rgb(255,255,255);\n}\n#text-892138462 > * {\n  color: rgb(255,255,255);\n}\n<\/style>\n\t<\/div>\n\t\n              <\/div>\n           <\/div>\n                            \n<style>\n#text-box-328657873 .text-box-content {\n  background-color: rgba(255, 255, 255, 0.16);\n  font-size: 100%;\n}\n#text-box-328657873 .text-inner {\n  padding: 0px 0px 0px 20px;\n}\n#text-box-328657873 {\n  width: 60%;\n}\n<\/style>\n    <\/div>\n \n        <\/div>\n      <\/div>\n\n            \n<style>\n#banner-741848340 {\n  padding-top: 600px;\n}\n#banner-741848340 .bg.bg-loaded {\n  background-image: url(https:\/\/www.pavlatou.gr\/wp-content\/uploads\/2024\/04\/national-cancer-institute-HMQtSQZHPZU-unsplash-1200x800.jpg);\n}\n#banner-741848340 .overlay {\n  background-color: rgba(0, 0, 0, 0.17);\n}\n<\/style>\n  <\/div>\n\n\n\t\t<\/div>\n\n\t\t\n<style>\n#section_882494936 {\n  padding-top: 30px;\n  padding-bottom: 30px;\n}\n<\/style>\n\t<\/section>\n\t\n\t<section class=\"section\" id=\"section_1270884111\">\n\t\t<div class=\"bg section-bg fill bg-fill  bg-loaded\" >\n\n\t\t\t\n\t\t\t\n\t\t\t\n\n\t\t<\/div>\n\n\t\t\n\n\t\t<div class=\"section-content relative\">\n\t\t\t\n<div class=\"row\"  id=\"row-1547425113\">\n\n\t<div id=\"col-1049561722\" class=\"col medium-3 small-12 large-3 col-divided\"  >\n\t\t\t\t<div class=\"col-inner text-left\"  >\n\t\t\t\n\t\t\t\n\t<div class=\"ux-menu stack stack-col justify-start ux-menu--divider-solid\">\n\t\t\n\t<div class=\"ux-menu-link flex menu-item first-menu-item\">\n\t\t<a class=\"ux-menu-link__link flex\" href=\"https:\/\/www.pavlatou.gr\/en\/gep-net\/#ti-einai\" >\n\t\t\t\t\t\t<span class=\"ux-menu-link__text\">\n\t\t\t\tWhat are the Neuroendocrine Tumours of the Gastroenteropancreatic System (GEP-NET) and how common are they?\t\t\t<\/span>\n\t\t<\/a>\n\t<\/div>\n\t\n\t<div class=\"ux-menu-link flex menu-item first-menu-item\">\n\t\t<a class=\"ux-menu-link__link flex\" href=\"https:\/\/www.pavlatou.gr\/en\/gep-net\/#ilikia-emfanisis\" >\n\t\t\t\t\t\t<span class=\"ux-menu-link__text\">\n\t\t\t\tAt what age do neuroendocrine tumours of the gastroenteropancreatic system (GEP-NET) occur?\t\t\t<\/span>\n\t\t<\/a>\n\t<\/div>\n\t\n\t<div class=\"ux-menu-link flex menu-item first-menu-item\">\n\t\t<a class=\"ux-menu-link__link flex\" href=\"https:\/\/www.pavlatou.gr\/en\/gep-net\/#ekdilosi\" >\n\t\t\t\t\t\t<span class=\"ux-menu-link__text\">\n\t\t\t\tHow do neuroendocrine tumours (NETs) of the digestive system present?\t\t\t<\/span>\n\t\t<\/a>\n\t<\/div>\n\t\n\t<div class=\"ux-menu-link flex menu-item first-menu-item\">\n\t\t<a class=\"ux-menu-link__link flex\" href=\"https:\/\/www.pavlatou.gr\/en\/gep-net\/#nhsidiwmata\" >\n\t\t\t\t\t\t<span class=\"ux-menu-link__text\">\n\t\t\t\tWhat are the Islet Cell tumours?\t\t\t<\/span>\n\t\t<\/a>\n\t<\/div>\n\t\n\t<div class=\"ux-menu-link flex menu-item first-menu-item\">\n\t\t<a class=\"ux-menu-link__link flex\" href=\"https:\/\/www.pavlatou.gr\/en\/gep-net\/#diagnosi\" >\n\t\t\t\t\t\t<span class=\"ux-menu-link__text\">\n\t\t\t\tHow are neuroendocrine tumours (NETs) of the digestive system diagnosed?\t\t\t<\/span>\n\t\t<\/a>\n\t<\/div>\n\t\n\t<div class=\"ux-menu-link flex menu-item first-menu-item\">\n\t\t<a class=\"ux-menu-link__link flex\" href=\"https:\/\/www.pavlatou.gr\/en\/gep-net\/#therapeia\" >\n\t\t\t\t\t\t<span class=\"ux-menu-link__text\">\n\t\t\t\tHow are neuroendocrine tumours (NETs) of the digestive system treated?\t\t\t<\/span>\n\t\t<\/a>\n\t<\/div>\n\t\n\t<\/div>\n\t\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\n\t\n\n\t<div id=\"col-368805822\" class=\"col medium-8 small-12 large-8\"  >\n\t\t\t\t<div class=\"col-inner\"  >\n\t\t\t\n\t\t\t\n<h2 id=\"ti-einai\" style=\"font-size: 20px;\">What are the Neuroendocrine Tumours of the Gastroenteropancreatic System (GEP-NET) and how common are they?<\/h2>\n<div class=\"is-divider divider clearfix\" style=\"max-width:30%;background-color:rgb(155, 0, 128);\"><\/div>\n\t<div id=\"gap-1384981328\" class=\"gap-element clearfix\" style=\"display:block; height:auto;\">\n\t\t\n<style>\n#gap-1384981328 {\n  padding-top: 20px;\n}\n<\/style>\n\t<\/div>\n\t\n<p>Neuroendocrine tumours (NETs) of the digestive system originate from the neuroendocrine cells of the gastrointestinal tract and <a href=\"https:\/\/www.pavlatou.gr\/en\/sakcharodis-diavitis\/#pagkreas\">pancreas<\/a>, with an incidence of 3.56 per 100,000 in the general population. The majority are well-differentiated, slow-growing tumours, with the minority showing aggressive behaviour.<\/p>\n<a href=\"https:\/\/www.pavlatou.gr\/en\/gep-net\/#ti-einai\" class=\"button secondary is-link is-xsmall lowercase\"  >\n    <span>Top<\/span>\n  <i class=\"icon-angle-right\" aria-hidden=\"true\" ><\/i><\/a>\n\n\t<div id=\"gap-1895366015\" class=\"gap-element clearfix\" style=\"display:block; height:auto;\">\n\t\t\n<style>\n#gap-1895366015 {\n  padding-top: 50px;\n}\n<\/style>\n\t<\/div>\n\t\n<h2 id=\"ilikia-emfanisis\" style=\"font-size: 20px;\">At what age do neuroendocrine tumours of the gastroenteropancreatic system (GEP-NET) occur?<\/h2>\n<div class=\"is-divider divider clearfix\" style=\"max-width:30%;background-color:rgb(155, 0, 128);\"><\/div>\n\t<div id=\"gap-1795284196\" class=\"gap-element clearfix\" style=\"display:block; height:auto;\">\n\t\t\n<style>\n#gap-1795284196 {\n  padding-top: 20px;\n}\n<\/style>\n\t<\/div>\n\t\n<p>They can occur at any age, but usually appear between the fourth and sixth decade.<\/p>\n<a href=\"https:\/\/www.pavlatou.gr\/en\/gep-net\/#ti-einai\" class=\"button secondary is-link is-xsmall lowercase\"  >\n    <span>Top<\/span>\n  <i class=\"icon-angle-right\" aria-hidden=\"true\" ><\/i><\/a>\n\n\t<div id=\"gap-1739418268\" class=\"gap-element clearfix\" style=\"display:block; height:auto;\">\n\t\t\n<style>\n#gap-1739418268 {\n  padding-top: 50px;\n}\n<\/style>\n\t<\/div>\n\t\n<h2 id=\"ekdilosi\" style=\"font-size: 20px;\">How do neuroendocrine tumours (NETs) of the digestive system present?<\/h2>\n<div class=\"is-divider divider clearfix\" style=\"max-width:30%;background-color:rgb(155, 0, 128);\"><\/div>\n\t<div id=\"gap-1172979675\" class=\"gap-element clearfix\" style=\"display:block; height:auto;\">\n\t\t\n<style>\n#gap-1172979675 {\n  padding-top: 20px;\n}\n<\/style>\n\t<\/div>\n\t\n<p>NETs of the digestive system usually develop as:<\/p>\n<ul>\n<li>Sporadic tumours, but may be related to the<\/li>\n<li>hereditary genetic endocrine tumour syndromes<\/li>\n<li>The majority of them are non-functional and the symptoms they give are mainly due to local compression or metastatic disease, such as:<\/li>\n<li>atypical abdominal pain<\/li>\n<\/ul>\n<p>However, these tumours may secrete active substances\/hormones, leading to separate clinical syndromes.<\/p>\n<a href=\"https:\/\/www.pavlatou.gr\/en\/gep-net\/#ti-einai\" class=\"button secondary is-link is-xsmall lowercase\"  >\n    <span>Top<\/span>\n  <i class=\"icon-angle-right\" aria-hidden=\"true\" ><\/i><\/a>\n\n\t<div id=\"gap-1171084730\" class=\"gap-element clearfix\" style=\"display:block; height:auto;\">\n\t\t\n<style>\n#gap-1171084730 {\n  padding-top: 50px;\n}\n<\/style>\n\t<\/div>\n\t\n<h2 id=\"nhsidiwmata\" style=\"font-size: 20px;\">What are the Islet Cell tumours?<\/h2>\n<div class=\"is-divider divider clearfix\" style=\"max-width:30%;background-color:rgb(155, 0, 128);\"><\/div>\n\t<div id=\"gap-2108239212\" class=\"gap-element clearfix\" style=\"display:block; height:auto;\">\n\t\t\n<style>\n#gap-2108239212 {\n  padding-top: 20px;\n}\n<\/style>\n\t<\/div>\n\t\n<p>Functional neuroendocrine tumours of the pancreas, i.e. tumours that originate from the islets of Langerhans and produce hormones, are also called islet cell tumours and are classified into the following types:<\/p>\n<ul>\n<li><a href=\"https:\/\/www.pavlatou.gr\/en\/insoylinoma\/\">Insulinoma<\/a><\/li>\n<li><a href=\"https:\/\/www.pavlatou.gr\/en\/gastrinoma\/\">Gastrinoma<\/a><\/li>\n<li><a href=\"https:\/\/www.pavlatou.gr\/en\/glukagonoma\/\">Glycagonoma<\/a><\/li>\n<li><a href=\"https:\/\/www.pavlatou.gr\/en\/vipoma\/\">VIPoma<\/a><\/li>\n<li><a href=\"https:\/\/www.pavlatou.gr\/en\/somatostatinoma\/\">Somatostatinoma<\/a><\/li>\n<\/ul>\n<a href=\"https:\/\/www.pavlatou.gr\/en\/gep-net\/#ti-einai\" class=\"button secondary is-link is-xsmall lowercase\"  >\n    <span>Top<\/span>\n  <i class=\"icon-angle-right\" aria-hidden=\"true\" ><\/i><\/a>\n\n\t<div id=\"gap-595987176\" class=\"gap-element clearfix\" style=\"display:block; height:auto;\">\n\t\t\n<style>\n#gap-595987176 {\n  padding-top: 20px;\n}\n<\/style>\n\t<\/div>\n\t\n\t<div id=\"gap-1317225414\" class=\"gap-element clearfix\" style=\"display:block; height:auto;\">\n\t\t\n<style>\n#gap-1317225414 {\n  padding-top: 50px;\n}\n<\/style>\n\t<\/div>\n\t\n<h2 id=\"diagnosi\" style=\"font-size: 20px;\">How are neuroendocrine tumours (NETs) of the digestive system diagnosed?<\/h2>\n<div class=\"is-divider divider clearfix\" style=\"max-width:30%;background-color:rgb(155, 0, 128);\"><\/div>\n\t<div id=\"gap-1821416469\" class=\"gap-element clearfix\" style=\"display:block; height:auto;\">\n\t\t\n<style>\n#gap-1821416469 {\n  padding-top: 20px;\n}\n<\/style>\n\t<\/div>\n\t\n<p>A significant number of these tumours are diagnosed incidentally on imaging tests performed for another disease.<\/p>\n<p>The diagnosis of <strong>gastrointestinal NETs<\/strong> is made by:<\/p>\n<ul>\n<li>cytology and confirmed by:<\/li>\n<li>biopsy, while the localisation of the tumour and the extent\/staging of the disease is determined by imaging studies, such as:<\/li>\n<li>CT and MRI,<\/li>\n<li>Somatostatin receptors scintigraphy (octreoscan) and<\/li>\n<li>endoscopic ultrasound.<\/li>\n<\/ul>\n<p>Their secretory capacity is determined by:<\/p>\n<ul>\n<li>measurement of the active substances excreted in the blood and urine.<\/li>\n<\/ul>\n<p>Similarly, the diagnosis of <strong>pancreatic NETs<\/strong> is made by:<\/p>\n<ul>\n<li>measurement of the hormone they secrete in excess and the localization of the tumour is done by:<\/li>\n<li>imaging modalities, while sometimes invasive diagnostic tests are required, such as:<\/li>\n<li>selective arterial calcium stimulation test<\/li>\n<\/ul>\n<a href=\"https:\/\/www.pavlatou.gr\/en\/gep-net\/#ti-einai\" class=\"button secondary is-link is-xsmall lowercase\"  >\n    <span>Top<\/span>\n  <i class=\"icon-angle-right\" aria-hidden=\"true\" ><\/i><\/a>\n\n\t<div id=\"gap-754468427\" class=\"gap-element clearfix\" style=\"display:block; height:auto;\">\n\t\t\n<style>\n#gap-754468427 {\n  padding-top: 50px;\n}\n<\/style>\n\t<\/div>\n\t\n<h2 id=\"therapeia\" style=\"font-size: 20px;\">How are neuroendocrine tumours (NETs) of the digestive system treated?<\/h2>\n<div class=\"is-divider divider clearfix\" style=\"max-width:30%;background-color:rgb(155, 0, 128);\"><\/div>\n\t<div id=\"gap-1599249281\" class=\"gap-element clearfix\" style=\"display:block; height:auto;\">\n\t\t\n<style>\n#gap-1599249281 {\n  padding-top: 20px;\n}\n<\/style>\n\t<\/div>\n\t\n<p>The treatment of choice for NETs is:<\/p>\n<ul>\n<li>their radical excision.<\/li>\n<\/ul>\n<p>In case of metastatic disease:<\/p>\n<ul>\n<li>surgical removal must be combined with other treatments, such as:<\/li>\n<li>chemoembolization for liver metastases,<\/li>\n<li>treatment with peptide receptor radionuclide and<\/li>\n<li>the targeted molecular therapies<\/li>\n<li>Somatostatin analogs have both anti-secretory and anti-tumoral effects.<\/li>\n<\/ul>\n<p><strong>Regular monitoring<\/strong> is important for early diagnosis of possible relapses and includes blood and imaging tests at intervals determined by the stage of the disease.<\/p>\n<a href=\"https:\/\/www.pavlatou.gr\/en\/gep-net\/#ti-einai\" class=\"button secondary is-link is-xsmall lowercase\"  >\n    <span>Top<\/span>\n  <i class=\"icon-angle-right\" aria-hidden=\"true\" ><\/i><\/a>\n\n\t<div id=\"gap-1141090045\" class=\"gap-element clearfix\" style=\"display:block; height:auto;\">\n\t\t\n<style>\n#gap-1141090045 {\n  padding-top: 50px;\n}\n<\/style>\n\t<\/div>\n\t\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\n\t\n<\/div>\n\t\t<\/div>\n\n\t\t\n<style>\n#section_1270884111 {\n  padding-top: 30px;\n  padding-bottom: 30px;\n}\n<\/style>\n\t<\/section>\n\t\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":5,"featured_media":0,"parent":0,"menu_order":561,"comment_status":"closed","ping_status":"closed","template":"page-blank.php","meta":{"footnotes":""},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.1 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Neuroendocrine Tumors of the Gastro-Entero-Pancreatic System |<\/title>\n<meta name=\"description\" content=\"Treatment of neuroendocrine tumors of the gastroenteropancreatic system by the experienced endocrinologist - diabetologist Dr. Maria Pavlatou.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pavlatou.gr\/en\/gep-net\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" 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